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BCL2L1 Antibody

CAT: 0223-13-079Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-13-079Size:100 µL
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Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
NCBI Gene ID
598
Swiss Prot
Q07817
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human BCL2L1 (NP_612815.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Autophagy, Cancer, Cell Cycle, Immunology, Neuroscience
Purification
Affinity purification
Positive Control
HT-29
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 30kDa
Fragment
IgG
Symbol
BCL2L1
Positive Control 2
B-cell
Positive Control 3
A-549
Positive Control 4
SW480
Positive Control 5
BT-474
Positive Control 6
K-562
NCBI Official Name
BCL2-like 1
NCBI Organism
Homo sapiens
Other Product Names
Bcl-xL Antibody: BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S, BCLX, Bcl-2-like protein 1, Apoptosis regulator Bcl-X, Bcl2-L-1
Tested Applications
WB, IF, IP
Physical Properties
Liquid

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