BCL2L1 Antibody

BCL2L1 encodes a protein which belongs to the BCL-2 protein family. The proteins encoded by BCL2L1 are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

598

Q07817

NP_612815

Human, Dog

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BCL2L1.

Unconjugated

Primary Antibodies

Transcription, Cancer

Antibody is purified by protein A chromatography method.

Cat. No. 1211 - HepG2 Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store BCL2L1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

26 kDa, 19 kDa

BCL2L1 antibody can be used for detection of BCL2L1 by ELISA at 1:312500. BCL2L1 antibody can be used for detection of BCL2L1 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

BCL2L1

BCL2-like 1

Homo sapiens

Allikmets, R., (2006) J. Mol. Biol. 356 (2), 367-381.

BCL2L1, BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS, BCLXL, BCLXS, PPP1R52

ELISA, WB

20336335