HMBS Antibody

CAT: 0223-30-974Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-30-974Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HMBS is a member of the hydroxymethylbilane synthase superfamily. It is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria.This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.
NCBI Gene ID
3145
Swiss Prot
P08397
Accession Number
NP_001019553
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HMBS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
721_B Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store HMBS antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
38 kDa
Applications Notes
HMBS antibody can be used for detection of HMBS by ELISA at 1:62500. HMBS antibody can be used for detection of HMBS by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
HMBS
NCBI Official Name
Hydroxymethylbilane synthase
NCBI Organism
Homo sapiens
Background Reference 01
Kuo, H.C., J. Neurol. Sci. 260 (1-2), 231-235 (2007) .
Other Product Names
HMBS, PBG-D, PBGD, UPS, PORC
Tested Applications
ELISA, WB
Protein ID
66933009
Physical Properties
Liquid

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