CD29 Antibody [HMb1-1]

• Background:

  The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain. It is expressed broadly on endothelial cells, epithelial, leukocytes, and smooth muscle. CD29 forms the VLA 1-6 complexes through the non-covalent interaction with the alpha integrins of CD49 a-f. The HMb1-1 antibody is capable of inhibiting T cell proliferation and blocking cell adhesion.

• NCBI Gene ID:

  16412;24511

• Swiss Prot:

  P09055

• Host:

  Hamster

• Reactivity:

  Mouse, Rat

• Clonality:

  Monoclonal

• Clone:

  HMb1-1

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Cancer

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Armenian Hamster IgG

• Specificity:

  The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain.

• Symbol:

  Itgb1

• NCBI Official Name:

  Integrin beta 1 (fibronectin receptor beta)

• NCBI Organism:

  Mus musculus; Rattus norvegicus

• Background Reference 01:

  Ridger, V. C., Wagner, B. E., Wallace, W. A., Hellewell, P. G. (2001) . Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation.The Journal of Immunology,166 (5), 3484-3490.

• Background Reference 02:

  Noto, K., Kato, K., Okumura, K., Yagita, H. (1995) . Identification and functional characterization of mouse CD29 with a mAb.International immunology,7 (5), 835-842.

• Background Reference 03:

  Sangaletti, S., Di Carlo, E., Gariboldi, S., Miotti, S., Cappetti, B., Parenza, M., ... Colombo, M. P. (2008) . Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.Cancer research,68 (21), 9050-9059.

• Other Product Names:

  CD29, Fnrb, gpIIa, Gm9863, AA409975, AA960159, 4633401G24Rik, ENSMUSG00000051907, Itgb1

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid