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EGLN3 Antibody

CAT: 0223-30-813Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-30-813Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
NCBI Gene ID
112399
Swiss Prot
Q9H6Z9
Accession Number
NP_071356
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EGLN3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10123 - Fetal Brain Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store EGLN3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
27 kDa
Applications Notes
EGLN3 antibody can be used for detection of EGLN3 by ELISA at 1:1562500. EGLN3 antibody can be used for detection of EGLN3 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
EGLN3
NCBI Official Name
Egl-9 family hypoxia-inducible factor 3
NCBI Organism
Homo sapiens
Background Reference 01
Ginouves, A., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (12), 4745-4750.
Other Product Names
EGLN3, FLJ21620, HIFPH3, MGC125998, MGC125999, PHD3, HIFP4H3
Tested Applications
ELISA, WB
Protein ID
11545787
Physical Properties
Liquid

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