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METAP2 Antibody

CAT: 0223-30-803Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-30-803Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site.This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
10988
Swiss Prot
P50579
Accession Number
NP_006829
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human METAP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10123 - Fetal Brain Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store METAP2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
53 kDa
Applications Notes
METAP2 antibody can be used for detection of METAP2 by ELISA at 1:312500. METAP2 antibody can be used for detection of METAP2 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
METAP2
NCBI Official Name
Methionyl aminopeptidase 2
NCBI Organism
Homo sapiens
Background Reference 01
Kass, D., (2007) Am. J. Respir. Cell Mol. Biol. 37 (2), 193-201.
Other Product Names
METAP2, MAP2, MNPEP, p67, p67eIF2
Tested Applications
ELISA, WB
Protein ID
5803092
Physical Properties
Liquid

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