PAXIP1 Antibody

• Background:

  PAXIP1 functions as a key component of the DNA damage response, and phosphoserine or phosphothreonine-specific binding modules. PAXIP1 recognizes substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3-related (ATR) in response to gamma irradiation. It may play a role in PAX2-dependent transcriptional regulation. PAXIP1 plays a role in early development, most probably in cell proliferation.

• NCBI Gene ID:

  22976

• Swiss Prot:

  Q6ZW49

• Accession Number:

  EAX04525

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PAXIP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  721_B Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PAXIP1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  74 kDa

• Applications Notes:

  PAXIP1 antibody can be used for detection of PAXIP1 by ELISA at 1:62500. PAXIP1 antibody can be used for detection of PAXIP1 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  PAXIP1

• NCBI Official Name:

  PAX interacting (with transcription-activation domain) protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PAXIP1, PTIP, TNRC2, CAGF28, CAGF29, PACIP1, PAXIP1L, FLJ41049

• Tested Applications:

  ELISA, WB

• Protein ID:

  119624930

• Physical Properties:

  Liquid