NR2C2 Antibody

• Background:

  Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes.Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes (Yoshikawa et al., 1996) .

• NCBI Gene ID:

  7182

• Swiss Prot:

  P49116

• Accession Number:

  NP_003289

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR2C2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Signal Transduction, Neuroscience

• Purification:

  Antibody is purified by protein A chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR2C2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  67 kDa

• Applications Notes:

  NR2C2 antibody can be used for detection of NR2C2 by ELISA at 1:312500. NR2C2 antibody can be used for detection of NR2C2 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  NR2C2

• NCBI Official Name:

  Nuclear receptor subfamily 2, group C, member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lin, W.J., (2003) J. Biol. Chem. 278 (11), 9353-9360.

• Other Product Names:

  NR2C2, TAK1, TR2R1, TR4, hTAK1

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  36950991

• Physical Properties:

  Liquid