PRPF19 Antibody

CAT: 0223-29-842Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-29-842Size:100 µL
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Background
PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.
NCBI Gene ID
27339
Swiss Prot
Q9UMS4
Accession Number
NP_055317
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRPF19.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Homeostasis
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PRPF19 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
55 kDa
Applications Notes
PRPF19 antibody can be used for detection of PRPF19 by ELISA at 1:312500. PRPF19 antibody can be used for detection of PRPF19 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PRPF19
NCBI Official Name
Pre-mRNA processing factor 19
NCBI Organism
Homo sapiens
Background Reference 01
Voglauer, R., (2006) Exp. Cell Res. 312 (6), 746-759.
Other Product Names
PRPF19, NMP200, PRP19, PSO4, UBOX4, hPSO4, SNEV
Tested Applications
ELISA, WB
Protein ID
7657381
Physical Properties
Liquid

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