P2RX7 Antibody

• Background :

  The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.

• NCBI Gene ID :

  5027

• Swiss Prot :

  Q4VKI1

• Accession Number :

  Q4VKI1

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human P2RX7.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Membrane, Cancer , Inflammasomes

• Purification :

  Antibody is purified by protein A chromatography method.

• Positive Control :

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store P2RX7 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  31 kDa

• Applications Notes :

  P2RX7 antibody can be used for detection of P2RX7 by ELISA at 1:312500. P2RX7 antibody can be used for detection of P2RX7 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  P2RX7

• NCBI Official Name :

  Purinergic receptor P2X, ligand-gated ion channel, 7

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Buell, GN., et al., (1998) Receptors Channels 5 (6) :347-54.

• Other Product Names :

  P2RX7, P2X7

• Tested Applications :

  ELISA, WB, IHC

• Protein ID :

  74753854

• Physical Properties :

  Liquid