DMAP1 Antibody

• Background :

  DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

• NCBI Gene ID :

  55929

• Swiss Prot :

  Q9NPF5

• Accession Number :

  NP_001029196

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Dog

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DMAP1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Homeostasis

• Purification :

  Antibody is purified by protein A chromatography method.

• Positive Control :

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store DMAP1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  51 kDa, 53 kDa, 53 kDa

• Applications Notes :

  DMAP1 antibody can be used for detection of DMAP1 by ELISA at 1:62500. DMAP1 antibody can be used for detection of DMAP1 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  DMAP1

• NCBI Official Name :

  DNA methyltransferase 1 associated protein 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Oh, J.H., et al., (2005) Mamm. Genome 16 (12), 942-954.

• Other Product Names :

  DMAP1, EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1

• Tested Applications :

  ELISA, WB

• Protein ID :

  78000213

• Physical Properties :

  Liquid