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APEX1 Antibody

CAT: 0223-27-662Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-662Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.
NCBI Gene ID
328
Swiss Prot
P27695
Accession Number
NP_542379
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human APEX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store APEX1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
35 kDa
Applications Notes
APEX1 antibody can be used for detection of APEX1 by ELISA at 1:312500. APEX1 antibody can be used for detection of APEX1 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
APEX1
NCBI Official Name
APEX nuclease (multifunctional DNA repair enzyme) 1
NCBI Organism
Homo sapiens
Background Reference 01
Ding, S.Z., et al., (2004) Gastroenterology 127 (3), 845-858.
Other Product Names
APEX1, APE, APX, APE1, APEN, APEX, HAP1, REF1
Tested Applications
ELISA, WB, IHC
Protein ID
18375503
Physical Properties
Liquid

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