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SKIIP Antibody

CAT: 0223-27-539Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-539Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SKIIP (Nuclear Protein SkiP, nuclear receptor coactivator NCoA-62, ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly (A) -binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
NCBI Gene ID
22938
Swiss Prot
Q13573
Accession Number
NP_036377
Host
Rabbit
Reactivity
Human, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SKIIP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SKIIP antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
61 kDa
Applications Notes
SKIIP antibody can be used for detection of SKIIP by ELISA at 1:62500. SKIIP antibody can be used for detection of SKIIP by western blot at 1.0-5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SNW1
NCBI Official Name
SNW domain containing 1
NCBI Organism
Homo sapiens
Background Reference 01
Figueroa, J.D., et al., (2004) Eur.Res.Commun.319 (4), 1105-1109.
Other Product Names
SKIIP, Bx42, SKIP, Prp45, SKIIP, PRPF45, NCOA-62
Tested Applications
ELISA, WB, IHC
Protein ID
6912676
Physical Properties
Liquid

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