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SkiP Antibody

CAT: 0223-2261-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2261-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SkiP Antibody: TGF-beta and the bone morphogenic proteins (BMPs) are key signaling proteins that regulate numerous cellular processes such as embryonic development and tumorigenesis. Both signal through the Smad protein family and are negatively regulated by Ski and SnoN, two related proto-oncoproteins. Ski functions by binding to the Smad proteins activated by TGF-beta and the (BMPs) and preventing their phosphorylation, inhibiting their ability to bind DNA and activate the transcription of downstream genes. SkiP was originally identified as a Ski-interacting protein and was later found to augment the signals induced by TGF-beta but inhibit transcription induced by BMP-2 in C2C12 cells, suggesting that SkiP is a key player in the signaling cascades inititated by TGF-beta and the BMP protein family.
NCBI Gene ID
22938
Swiss Prot
Q13573
Accession Number
NP_036377
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
SkiP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
SkiP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SkiP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SNW1
Positive Control 2
Cat. No. 1305 - Human Kidney Tissue Lysate
Positive Control 3
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
SNW domain containing 1
NCBI Organism
Homo sapiens
Background Reference 01
Derynck R, Akhurst RJ, and Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 2001; 29:117-129.
Background Reference 02
Li Y, Turck CM, Teumer JK, et al. Unique sequence, SkiP, in Sloan-Kettering avian retrovirus with properties of a new cell-derived oncogene. J. Virol. 1986; 57:1065-72.
Background Reference 03
Luo K. SkiP and SkiP: negative regulators of TGF-β signaling. Curr. Op. Gen. Dev. 2004; 14:65-70.
Background Reference 04
Massague J and Wotton D. Transcriptional control by the TGF-b/Smad signaling system. EMBO J. 2000; 19:1745-54.
Other Product Names
SkiP Antibody: Bx42, SKIP, Prp45, SKIIP, PRPF45, NCOA-62, SNW domain-containing protein 1, Nuclear protein SkiP
Tested Applications
ELISA, WB, IF
Protein ID
6912676
Physical Properties
Liquid

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