LMX1A Antibody

CAT: 0223-27-470Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-470Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin. Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]) .[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-199 AL160058.8 14249-14447 c 200-2447 AK127724.1 362-2609 2448-3382 AL390730.12 9415-10349 c
NCBI Gene ID
4009
Swiss Prot
Q8TE12
Accession Number
NP_796372
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LMX1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
721_B Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store LMX1A antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
43 kDa
Applications Notes
LMX1A antibody can be used for detection of LMX1A by ELISA at 1:62500. LMX1A antibody can be used for detection of LMX1A by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
LMX1A
NCBI Official Name
LIM homeobox transcription factor 1, alpha
NCBI Organism
Homo sapiens
Background Reference 01
Gregory, S.G., (2006) Nature 441 (7091), 315-321.
Other Product Names
LMX1A, LMX-1, LMX1, LMX1.1, MGC87616
Tested Applications
ELISA, WB
Protein ID
28893581
Physical Properties
Liquid

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