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LMX1B Antibody

CAT: 0223-7089-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7089-01Size:0.02 mg
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Background
LMX1B Antibody: The LIM homeobox transcription factor 1B (LMX1B) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning; LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.
NCBI Gene ID
4010
Swiss Prot
O60663
Accession Number
NP_001167617
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
LMX1B Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
LMX1B Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LMX1B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
IgG
Specificity
At least three isoforms are known to exist. This antibody is predicted to not cross-react with LMX1A.
Symbol
LMX1B
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
LIM homeobox transcription factor 1, beta
NCBI Organism
Homo sapiens
Background Reference 01
Hobert O and Westphal H. Functions of LIM-homeobox genes. Trends Genet. 2000; 16:75-83.
Background Reference 02
Nakatani T, Kumai M, Mizuhara E, et al. Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. Dev. Biol. 2010; 339:101-13.
Background Reference 03
Guo C, Qiu HY, Huang Y, et al. Lmx1b is essential for FGF8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development 2007; 134:317-25.
Background Reference 04
Chizhikov VV and Millen KJ. Control of roof plate formation by LMX1A in the developing spinal cord. Development 2004; 131:2693-705.
Other Product Names
LMX1B Antibody: NPS1, LMX1.2, LIM homeobox transcription factor 1-beta
Tested Applications
ELISA, WB
Protein ID
292494913
Physical Properties
Liquid

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