AATF Antibody

• Background:

  The AATF gene encodes a protein that was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

• NCBI Gene ID:

  26574

• Swiss Prot:

  Q9NY61

• Accession Number:

  NP_036270

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human AATF.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer, Apoptosis

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10408 - Fetal Kidney Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store AATF antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  63 kDa

• Applications Notes:

  AATF antibody can be used for detection of AATF by ELISA at 1:12500. AATF antibody can be used for detection of AATF by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  AATF

• NCBI Official Name:

  Apoptosis antagonizing transcription factor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Burgdorf, S., et al., (2004) J. Biol. Chem. 279 (17), 17524-17534.

• Other Product Names:

  AATF, DED, BFR2, CHE1, CHE-1

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  7657013

• Physical Properties:

  Liquid