HMBS Antibody

• Background:

  HMBS is a member of the hydroxymethylbilane synthase superfamily. It is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria.This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

• NCBI Gene ID:

  3145

• Swiss Prot:

  P08397

• Accession Number:

  NP_000181

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HMBS.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store HMBS antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  40 kDa

• Applications Notes:

  HMBS antibody can be used for detection of HMBS by ELISA at 1:312500. HMBS antibody can be used for detection of HMBS by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  HMBS

• NCBI Official Name:

  Hydroxymethylbilane synthase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kuo, H.C., J. Neurol. Sci. 260 (1-2), 231-235 (2007) .

• Other Product Names:

  HMBS, PBG-D, PBGD, UPS, PORC

• Tested Applications:

  ELISA, WB

• Protein ID:

  20149500

• Physical Properties:

  Liquid