PSMC3IP Antibody

• Background:

  PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.

• NCBI Gene ID:

  29893

• Swiss Prot:

  Q9P2W1-2

• Accession Number:

  NP_037422

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PSMC3IP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  721_B Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PSMC3IP antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  24 kDa

• Applications Notes:

  PSMC3IP antibody can be used for detection of PSMC3IP by ELISA at 1:1562500. PSMC3IP antibody can be used for detection of PSMC3IP by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  PSMC3IP

• NCBI Official Name:

  PSMC3 interacting protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Enomoto, R., (2006) J. Biol. Chem. 281 (9), 5575-5581.

• Other Product Names:

  PSMC3IP, GT198, HOP2, TBPIP, ODG3, HUMGT198A

• Tested Applications:

  ELISA, WB

• Protein ID:

  32261320

• Physical Properties:

  Liquid