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PI3 Antibody

CAT: 0223-26-045Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-26-045Size:100 µL
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Background
PI3 is an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. PI3 contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. PI3 belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.This gene encodes an elastase-specific inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
5266
Swiss Prot
P19957
Accession Number
NP_002629
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PI3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
721_B Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PI3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
6 kDa
Applications Notes
PI3 antibody can be used for detection of PI3 by ELISA at 1:312500. PI3 antibody can be used for detection of PI3 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PI3
NCBI Official Name
Peptidase inhibitor 3, skin-derived
NCBI Organism
Homo sapiens
Background Reference 01
Wang, Z., (2008) Am. J. Respir. Cell Mol. Biol. 38 (6), 724-732.
Other Product Names
PI3, ESI, MGC13613, SKALP, WAP3, WFDC14, cementoin
Tested Applications
ELISA, WB
Protein ID
4505787
Physical Properties
Liquid

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