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CYP46A1 Antibody

CAT: 0223-25-885Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-25-885Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CYP46A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
10858
Swiss Prot
Q9Y6A2
Accession Number
NP_006659
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CYP46A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Neuroscience
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CYP46A1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
57 kDa
Applications Notes
CYP46A1 antibody can be used for detection of CYP46A1 by ELISA at 1:312500. CYP46A1 antibody can be used for detection of CYP46A1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
CYP46A1
NCBI Official Name
Cytochrome P450, family 46, subfamily A, polypeptide 1
NCBI Organism
Homo sapiens
Background Reference 01
Galluzzi, S., (2008) J. Gerontol. A Biol. Sci. Med. Sci. 63 (5), 510-517.
Other Product Names
CYP46A1, CP46, CYP46
Tested Applications
ELISA, WB
Protein ID
5729796
Physical Properties
Liquid

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