CYP26A1 Antibody

• Background:

  CYP26A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues.

• NCBI Gene ID:

  1592

• Swiss Prot:

  O43174

• Accession Number:

  O43174

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CYP26A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the Central region of human CYP26A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CYP26A1

• NCBI Official Name:

  Cytochrome P450 26A1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Quere, R., Blood 109 (10), 4450-4460 (2007)

• Background Reference 02:

  Lee, S.J., Pharmacogenet. Genomics 17 (3), 169-180 (2007)

• Background Reference 03:

  Heise, R., J. Invest. Dermatol. 126 (11), 2473-2480 (2006)

• Other Product Names:

  Cytochrome P450 26A1, 114--, Cytochrome P450 retinoic acid-inactivating 1, Cytochrome P450RAI, hP450RAI, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome, CYP26A1, CYP26, P450RAI1

• Tested Applications:

  WB

• Physical Properties:

  Liquid