CYP24A1 Antibody

• Background:

  CYP24A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system.

• NCBI Gene ID:

  1591

• Swiss Prot:

  Q07973

• Accession Number:

  Q07973

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CYP24A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-494 amino acids from the C-terminal region of human CYP24A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CYP24A1

• NCBI Official Name:

  1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Okuda, K., et.al., J. Lipid Res. 36 (8), 1641-1652 (1995)

• Background Reference 02:

  Bosse, Y., et.al., Respir. Res. 10, 98 (2009)

• Other Product Names:

  25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial, 24-OHase, Vitamin D (3) 24-hydroxylase, Cytochrome P450 24A1, Cytochrome P450-CC24, CYP24A1, CYP24

• Tested Applications:

  WB, IHC-P

• Protein ID:

  19862747

• Physical Properties:

  Liquid