TPM3 Antibody

TPM3 is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer.This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

7170

P06753

NP_705935

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TPM3.

Unconjugated

Primary Antibodies

Cancer

Antibody is purified by peptide affinity chromatography method.

Cat. No. 1208 - THP-1 Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TPM3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

33 kDa

TPM3 antibody can be used for detection of TPM3 by ELISA at 1:312500. TPM3 antibody can be used for detection of TPM3 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

TPM3

Tropomyosin 3

Homo sapiens

Clarke, N.F., (2008) Ann. Neurol. 63 (3), 329-337.

TPM3, FLJ41118, MGC14582, MGC3261, MGC72094, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TPMsk3, TRK, hscp30, TM5, CFTD, CAPM1, HEL-189, HEL-S-82p

ELISA, WB

24119203