TPM4 Antibody

• Background:

  This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  7171

• Swiss Prot:

  P67936

• Accession Number:

  P67936

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human TPM4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TPM4

• NCBI Official Name:

  Tropomyosin alpha-4 chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martins-de-Souza, D., et al.Psychiatr Res 44 (14) :989-991 (2010)

• Background Reference 02:

  Vlahovich, N., et al. Cell Motil. Cytoskeleton 65 (1) :73-85 (2008)

• Background Reference 03:

  Montesano Gesualdi, N., et al. Free Radic. Res. 40 (5) :467-476 (2006)

• Background Reference 04:

  Hossain, M.M., et al. J. Biol. Chem. 280 (51) :42442-42453 (2005)

• Other Product Names:

  Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4

• Tested Applications:

  WB, Flow

• Protein ID:

  54039751

• Physical Properties:

  Liquid