AHRR Antibody

Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction with the receptor's binding partner, arylhydrocarbon receptor nuclear translocator. AHRR represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, AHRR can bind to nuclear factor kappa-B.Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction with the receptor's binding partner, arylhydrocarbon receptor nuclear translocator. The protein encoded by this gene represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

57491

A9YTQ3

NP_065782

Human

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human AHRR.

Unconjugated

Primary Antibodies

Transcription, Cancer, Signal Transduction

Antibody is purified by peptide affinity chromatography method.

Cat. No. 1211 - HepG2 Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store AHRR antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

78 kDa

AHRR antibody can be used for detection of AHRR by ELISA at 1:312500. AHRR antibody can be used for detection of AHRR by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

AHRR

Aryl-hydrocarbon receptor repressor

Homo sapiens

Zudaire, E., (2008) J. Clin. Invest. 118 (2), 640-650.

AHRR, AHH, AHHR, KIAA1234, MGC167813, MGC176630, bHLHe77

ELISA, WB

115430245