STAT3 Antibody

STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. It mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

6774

B5BTZ6

NP_003141

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human STAT3.

Unconjugated

Primary Antibodies

Transcription, Cancer, Signal Transduction, Immunology, Neuroscience

Antibody is purified by peptide affinity chromatography method.

Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store STAT3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

88 kDa

STAT3 antibody can be used for detection of STAT3 by ELISA at 1:1562500. STAT3 antibody can be used for detection of STAT3 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

STAT3

Signal transducer and activator of transcription 3 (acute-phase response factor)

Homo sapiens

Ohbayashi, N., (2008) Biochem. Biophys. Res. Commun. 371 (4), 823-828.

STAT3, APRF, FLJ20882, MGC16063, HIES

ELISA, WB

21618338