L3MBTL Antibody

• Background:

  L3MBTL is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells.This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

• NCBI Gene ID:

  26013

• Swiss Prot:

  Q9Y468

• Accession Number:

  NP_056293

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human L3MBTL.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10123 - Fetal Brain Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store L3MBTL antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  86 kDa

• Applications Notes:

  L3MBTL antibody can be used for detection of L3MBTL by ELISA at 1:1562500. L3MBTL antibody can be used for detection of L3MBTL by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  L3MBTL1

• NCBI Official Name:

  L (3) mbt-like 1 (Drosophila)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Min, J., (2007) Nat. Struct. Mol. Biol. 14 (12), 1229-1230.

• Other Product Names:

  L3MBTL, DKFZp586P1522, FLJ41181, H-L (3) MBT, KIAA0681, L3MBTL1, dJ138B7.3, L3MBTL, ZC2HC3

• Tested Applications:

  ELISA, WB

• Protein ID:

  117938328

• Physical Properties:

  Liquid