PFKFB2 Antibody

• Background:

  The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.

• NCBI Gene ID:

  5208

• Swiss Prot:

  O60825

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 446-505 of human PFKFB2 (NP_006203.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  A-549

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 54kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  PFKFB2

• Positive Control 2:

  Mouse liver

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Mouse skeletal muscle

• Positive Control 5:

  Rat liver

• NCBI Official Name:

  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PFKFB2, fructose-2, 6-bisphosphatase, cardiac isozyme, PFKFB, cardiac, OTTHUMP00000034286, OTTHUMP00000034285, 6PF-2-K/Fru-2, 6-P2ASE heart-type isozyme, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2, PFK-2/FBPase-2, MGC138310, MGC138308, DKFZp781D2217, 6-biphosphatase 2, PFKFB2

• Tested Applications:

  WB

• Physical Properties:

  Liquid