SOST Antibody

• Background:

  Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

• NCBI Gene ID:

  50964

• Swiss Prot:

  Q9BQB4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 24-213 of human SOST (NP_079513.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 30kDa

• Fragment:

  IgG

• Symbol:

  SOST

• Positive Control 2:

  HepG2

• NCBI Official Name:

  Sclerostin

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SOST, sclerosteosis, VBCH, sclerostin

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid