CFL2 Antibody

• Background:

  This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  1073

• Swiss Prot:

  Q9Y281

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CFL2 (NP_068733.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  A-549

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 18kDa

• Fragment:

  IgG

• Symbol:

  CFL2

• Positive Control 2:

  HeLa

• Positive Control 3:

  Raji

• Positive Control 4:

  NCI-H460

• Positive Control 5:

  Mouse heart

• Positive Control 6:

  Mouse skeletal muscle

• NCBI Official Name:

  Cofilin 2 (muscle)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Cofilin 2, NEM7, CFL2, HGNC:1875, cofilin 2 (muscle)

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid