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CALM2 Antibody

CAT: 0223-23-348Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-23-348Size:100 µL
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Background
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215) . Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT) (PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
805
Swiss Prot
P62158
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
NIH/3T3
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 17kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CALM2
Positive Control 2
MCF7
Positive Control 3
BT-474
Positive Control 4
NCI-H460
Positive Control 5
Mouse brain
NCBI Official Name
Calmodulin 1 (phosphorylase kinase, delta)
NCBI Organism
Homo sapiens
Other Product Names
CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII, CalmodulinCaM, caM, CAMI, PHKD, CPVT4, DD132
Tested Applications
WB
Physical Properties
Liquid

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