PRMT6 Antibody

• Background:

  The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.

• NCBI Gene ID:

  55170

• Swiss Prot:

  Q96LA8

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human PRMT6 (NP_060607.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 42kDa

• Fragment:

  IgG

• Symbol:

  PRMT6

• Positive Control 2:

  SKOV3

• Positive Control 3:

  MCF7

• NCBI Official Name:

  Protein arginine methyltransferase 6

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  FLJ10559, FLJ51477, heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, histone-arginine N-methyltransferase PRMT6, HMT1 hnRNP methyltransferase-like 6, HRMT1L6, OTTHUMP00000012633, PRMT6, protein arginine methyltransferase 6, protein arginine N-methyltransferase 6

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid