PRMT5 Antibody

CAT: 0223-55-030Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-030Size:400 µL
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Background
Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.
NCBI Gene ID
10419
Swiss Prot
O14744
Accession Number
O14744
Host
Rabbit
Reactivity
Human
Immunogen
This PRMT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-499 amino acids from the C-terminal region of human PRMT5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
73 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PRMT5
NCBI Official Name
Protein arginine N-methyltransferase 5
NCBI Organism
Homo sapiens
Background Reference 01
Pal, S., et al., Mol. Cell. Biol. 23 (21) :7475-7487 (2003) .
Background Reference 02
Rho, J., et al., J. Biol. Chem. 276 (14) :11393-11401 (2001) .
Background Reference 03
Pollack, B.P., et al., J. Biol. Chem. 274 (44) :31531-31542 (1999) .
Background Reference 04
Gilbreth, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (25) :14781-14786 (1998) .
Other Product Names
Protein arginine N-methyltransferase 5, 211-, 72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs, Protein arginine N-methyltransferase 5, N-terminally processed, PRMT5, HRMT1L5, IBP72, JBP1, SKB1
Tested Applications
WB
Physical Properties
Liquid

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