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TP53I3 Antibody

CAT: 0223-23-037Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-23-037Size:100 µL
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Background
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
9540
Swiss Prot
Q53FA7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 163-332 of human TP53I3 (NP_671713.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 37kDa/72kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
TP53I3
Positive Control 2
A-549
Positive Control 3
SW480
Positive Control 4
SW620
Positive Control 5
HepG2
Positive Control 6
Mouse kidney
NCBI Official Name
Quinone oxidoreductase PIG3
NCBI Organism
Homo sapiens
Other Product Names
Quinone oxidoreductase PIG3, 1---, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein, TP53I3, PIG3
Tested Applications
WB
Physical Properties
Liquid

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