STAT4 Antibody

• Background:

  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

• NCBI Gene ID:

  6775

• Swiss Prot:

  Q14765

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 569-748 of human STAT4 (NP_003142.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction, Transcription

• Purification:

  Affinity purification

• Positive Control:

  NCI-H460

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 76kDa

• Fragment:

  IgG

• Symbol:

  STAT4

• NCBI Official Name:

  Signal transducer and activator of transcription 4

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  STAT4, SLEB11

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid