PSMD8 Antibody

• Background:

  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.

• NCBI Gene ID:

  5714

• Swiss Prot:

  P48556

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 101-350 of human PSMD8 (NP_002803.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  SGC-7901

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 30-35kDa

• Fragment:

  IgG

• Symbol:

  PSMD8

• Positive Control 2:

  Jurkat

• Positive Control 3:

  SW480

• Positive Control 4:

  U-87MG

• Positive Control 5:

  Mouse testis

• Positive Control 6:

  Mouse skeletal muscle

• NCBI Official Name:

  Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PSMD8, HIP6, HYPF, MGC1660, Nin1p, Rpn12, S14, p31, HEL-S-91n

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid