PPOX Antibody

• Background:

  This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.

• NCBI Gene ID:

  5498

• Swiss Prot:

  P50336

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PPOX (NP_001116236.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 51kDa

• Fragment:

  IgG

• Symbol:

  PPOX

• Positive Control 2:

  Mouse spleen

• Positive Control 3:

  Mouse liver

• Positive Control 4:

  Mouse kidney

• NCBI Official Name:

  Protoporphyrinogen oxidase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PPO, V290M, VP, protoporphyrinogen oxidase

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid