AKTIP Antibody

• Background:

  The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB) /Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

• NCBI Gene ID:

  64400

• Swiss Prot:

  Q9H8T0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human AKTIP (NP_071921.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 36kDa

• Fragment:

  IgG

• Symbol:

  AKTIP

• Positive Control 2:

  MCF7

• Positive Control 3:

  293T

• Positive Control 4:

  Mouse brain

• Positive Control 5:

  Rat kidney

• NCBI Official Name:

  AKT-interacting protein

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid