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AKTIP Antibody

CAT: 0223-60-501Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-501Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB) /Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
NCBI Gene ID
64400
Swiss Prot
Q9H8T0
Accession Number
Q9H8T0
Host
Rabbit
Reactivity
Human
Immunogen
This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AKTIP
NCBI Official Name
AKT-interacting protein
NCBI Organism
Homo sapiens
Background Reference 01
Notaridou, M., et al. Int. J. Cancer (2010) In press :
Background Reference 02
Quaye, L., et al. Hum. Mol. Genet. 18 (10) :1869-1878 (2009)
Background Reference 03
Xu, L., et al. Mol. Biol. Cell 19 (12) :5059-5071 (2008)
Background Reference 04
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Other Product Names
AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS
Tested Applications
WB
Protein ID
54035954
Physical Properties
Liquid

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