AKTIP Antibody

• Background:

  The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB) /Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

• NCBI Gene ID:

  64400

• Swiss Prot:

  Q9H8T0

• Accession Number:

  Q9H8T0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  AKTIP

• NCBI Official Name:

  AKT-interacting protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Notaridou, M., et al. Int. J. Cancer (2010) In press :

• Background Reference 02:

  Quaye, L., et al. Hum. Mol. Genet. 18 (10) :1869-1878 (2009)

• Background Reference 03:

  Xu, L., et al. Mol. Biol. Cell 19 (12) :5059-5071 (2008)

• Background Reference 04:

  Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

• Other Product Names:

  AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS

• Tested Applications:

  WB

• Protein ID:

  54035954

• Physical Properties:

  Liquid