FUS Antibody, KO Validated

• Background:

  This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

• NCBI Gene ID:

  2521

• Swiss Prot:

  P35637

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 297-526 of human FUS (NP_004951.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Cancer, Signal Transduction, Transcription

• Purification:

  Affinity purification

• Positive Control:

  U-937

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 70kDa

• Fragment:

  IgG

• Symbol:

  FUS

• Positive Control 2:

  Jurkat

• NCBI Official Name:

  Fused in sarcoma

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  FUS, FUS-CHOP, FUS1, TLS, ALS6, ETM4, POMP75, HNRNPP2

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid