SMARCA4 Antibody, KO Validated

• Background:

  The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  6597

• Swiss Prot:

  P51532

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 30-130 of human SMARCA4 (NP_003063.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Cancer, Neuroscience, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  OVCAR3

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 180kDa

• Fragment:

  IgG

• Symbol:

  SMARCA4

• Positive Control 2:

  HeLa

• NCBI Official Name:

  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SMARCA4 Antibody: BRG1, SNF2, SWI2, MRD16, RTPS2, BAF190, SNF2L4, SNF2LB, hSNF2b, BAF190A, BRG1, SNF2B, Transcription activator BRG1, ATP-dependent helicase SMARCA4

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid