TRAF2 Antibody, KO Validated

CAT: 0223-13-338Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-13-338Size:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
NCBI Gene ID
7186
Swiss Prot
Q12933
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2 (NP_066961.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Apoptosis, Autophagy, Cancer, Cell Cycle, Growth Factors, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 54kDa
Fragment
IgG
Symbol
TRAF2
Positive Control 2
293T
Positive Control 3
THP-1
Positive Control 4
PC-12
Positive Control 5
Ramos
Positive Control 6
Jurkat
NCBI Official Name
TNF receptor-associated factor 2
NCBI Organism
Homo sapiens
Other Product Names
TRAF2 Antibody: TRAP, TRAP3, MGC:45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2
Tested Applications
WB, IF, IP
Physical Properties
Liquid

Related Products

CatalogName
23-429POR Antibody, KO Validated
13-078BAX Antibody, KO Validated
13-267CSK Antibody, KO Validated
13-315SMARCA4 Antibody, KO Validated
13-327PARP1 Antibody, KO Validated
13-355PARK7 Antibody, KO Validated
13-390UBE2O Antibody, KO Validated
13-578DFFA Antibody, KO Validated
13-583ENO1 Antibody, KO Validated
13-968SIRT1 Antibody, KO Validated

Alternative Products

CatalogName
AF5327TRAF2 Rabbit Polyclonal Antibody (KO Validated)
E45R17601N-50[KO Validated] TRAF2 Rabbit pAb
A22374[KD Validated] TRAF2 Rabbit mAb
A106606Anti-[KD Validated] TRAF2 (Rabbit, Monoclonal)
APR17601N-01[KO Validated] TRAF2 Rabbit pAb (APR17601N)
MBS8515470-01TRAF2 Antibody
ABD6146TRAF2 Antibody

Popular Products