FADD Antibody

• Background:

  The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

• NCBI Gene ID:

  8772

• Swiss Prot:

  Q13158

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Inflammasomes

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 26kDa

• Fragment:

  IgG

• Symbol:

  FADD

• Positive Control 2:

  MCF7

• Positive Control 3:

  HeLa

• Positive Control 4:

  Mouse liver

• Positive Control 5:

  Mouse kidney

• Positive Control 6:

  Mouse heart

• NCBI Official Name:

  Fas (TNFRSF6) -associated via death domain

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  FADD, GIG3, MORT1

• Tested Applications:

  WB, IHC, IP

• Physical Properties:

  Liquid