RAG2 Antibody

• Background :

  This gene encodes a protein that is involved in the initiation of V (D) J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

• NCBI Gene ID :

  5897

• Swiss Prot :

  P55895

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 258-527 of human RAG2 (NP_001230715.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  Raji

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 59kDa

• Fragment :

  IgG

• Symbol :

  RAG2

• Positive Control 2 :

  Jurkat

• Positive Control 3 :

  293T

• Positive Control 4 :

  HepG2

• NCBI Official Name :

  Recombination activating 2

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  RAG-2, V (D) J recombination-activating protein 2, recombination activating gene 2

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid