PCSK5 Antibody

• Background:

  This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B) .

• NCBI Gene ID:

  5125

• Swiss Prot:

  Q92824

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 601-913 of human PCSK5 (NP_006191.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  Jurkat

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 102kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  PCSK5

• Positive Control 2:

  SW480

• Positive Control 3:

  Mouse lung

• Positive Control 4:

  Rat lung

• Positive Control 5:

  Rat brain

• NCBI Official Name:

  Proprotein convertase subtilisin/kexin type 5

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PCSK5, subtilisin/kexin-like protease PC5, protease PC6, proprotein convertase PC5, prohormone convertase 5, OTTHUMP00000063532, SPC6, PC6A, PC6, PC5, proprotein convertase subtilisin/kexin type 5, PCSK5

• Tested Applications:

  WB

• Physical Properties:

  Liquid