PCSK7 Antibody

• Background:

  The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.

• NCBI Gene ID:

  9159

• Swiss Prot:

  Q16549

• Accession Number:

  Q16549

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PCSK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human PCSK7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  86 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PCSK7

• NCBI Official Name:

  Proprotein convertase subtilisin/kexin type 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leonhardt, R.M., et al. J. Immunol. 184 (6) :2985-2998 (2010)

• Background Reference 02:

  McColl, B.K., et al. FASEB J. 21 (4) :1088-1098 (2007)

• Background Reference 03:

  Bruzzaniti, A., et al. Peptides 23 (5) :863-875 (2002)

• Background Reference 04:

  Fugere, M., et al. J. Biol. Chem. 277 (10) :7648-7656 (2002)

• Other Product Names:

  Proprotein convertase subtilisin/kexin type 7, 3421-, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, PC7, Proprotein convertase 8, PC8, hPC8, Subtilisin/kexin-like protease PC7, PCSK7, LPC, PC7, PC8, SPC7

• Tested Applications:

  WB

• Protein ID:

  205830663

• Physical Properties:

  Liquid