PSMC6 Antibody

CAT: 0223-19-626Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-19-626Size:100 µL
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Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
NCBI Gene ID
5706
Swiss Prot
P62333
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PSMC6 (NP_002797.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
Affinity purification
Positive Control
NCI-H460
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 45kDa
Fragment
IgG
Symbol
PSMC6
Positive Control 2
293T
Positive Control 3
SH-SY5Y
Positive Control 4
Mouse liver
Positive Control 5
Mouse kidney
Positive Control 6
Mouse brain
NCBI Official Name
Proteasome 26S subunit, ATPase 6
NCBI Organism
Homo sapiens
Other Product Names
SUG2, p42, 26S proteasome regulatory subunit 10B, 26S proteasome AAA-ATPase subunit RPT4, proteasome (prosome, macropain) 26S subunit, ATPase, 6, proteasome subunit p42
Tested Applications
WB, IHC
Physical Properties
Liquid

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