PSMC6 Antibody

• Background :

  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

• NCBI Gene ID :

  5706

• Swiss Prot :

  P62333

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PSMC6 (NP_002797.3) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  Affinity purification

• Positive Control :

  NCI-H460

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 45kDa

• Fragment :

  IgG

• Symbol :

  PSMC6

• Positive Control 2 :

  293T

• Positive Control 3 :

  SH-SY5Y

• Positive Control 4 :

  Mouse liver

• Positive Control 5 :

  Mouse kidney

• Positive Control 6 :

  Mouse brain

• NCBI Official Name :

  Proteasome 26S subunit, ATPase 6

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  SUG2, p42, 26S proteasome regulatory subunit 10B, 26S proteasome AAA-ATPase subunit RPT4, proteasome (prosome, macropain) 26S subunit, ATPase, 6, proteasome subunit p42

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid