IMPDH2 Antibody

• Background:

  This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

• NCBI Gene ID:

  3615

• Swiss Prot:

  P12268

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Growth Factors, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 56kDa

• Fragment:

  IgG

• Symbol:

  IMPDH2

• Positive Control 2:

  PC-3

• Positive Control 3:

  Raji

• Positive Control 4:

  Jurkat

• Positive Control 5:

  Mouse spleen

• Positive Control 6:

  Mouse skeletal muscle

• NCBI Official Name:

  IMP (inosine 5'-monophosphate) dehydrogenase 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  IMPDH2, IMPD2, IMPDH-II

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid