IMPDH1 Antibody

• Background:

  The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP) . This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10) . Several transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  3614

• Swiss Prot:

  P20839

• Accession Number:

  P20839

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This IMPDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-514 amino acids from the C-terminal region of human IMPDH1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IMPDH1

• NCBI Official Name:

  Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ohmann, E.L., et al. Pediatr Transplant 14 (7) :891-895 (2010) Gensburger, O., et al. Pharmacogenet. Genomics 20 (9) :537-543 (2010) Kagaya, H., et al. Basic Clin. Pharmacol. Toxicol. 107 (2) :631-636 (2010) Ohmann, E.L., et al. J. Heart Lung Transplant. 29 (5) :509-516 (2010) Shumei, L., et al. Adv. Exp. Med. Biol. 664, 293-297 (2010) :

• Other Product Names:

  Inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 1 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-I, IMPDH1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD1

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  25014074

• Physical Properties:

  Liquid